The prevalence of HBV, HTLV, HIV and concurrent infections in blood recipients of the South African National Blood Service (SANBS)

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dc.contributor.authorWillemse, Reynier
dc.contributor.co-supervisorVermeulen, M.
dc.contributor.supervisorGrobler, C. J., Dr.
dc.date.accessioned2022-12-05T01:10:28Z
dc.date.available2022-12-05T01:10:28Z
dc.date.issued2020-12
dc.descriptionM. Tech. (Department of Biotechnology, Faculty of Applied and Computer Sciences), Vaal University of Technology.en_US
dc.description.abstractBackground: Currently, the South African National Blood Services are not testing for HTLV and HTLV screening is not mandated by the WHO or by regulatory standards in South Africa. Looking at the uniquely high prevalence of HIV and HIV / HBV co-infections in the South African population and taking into account the literature that suggests that most of these infected patients will be receiving blood, exposing these patients to an additional burden like HTLV can result in an increased disease progression of HIV to AIDS and a poor prognosis in these infected patients. Study design and methods: A blinded cross-sectional study was performed. 7015 specimens were collected from all blood transfusion laboratories across South Africa excluding the Western Cape Blood Transfusion Service laboratories. The specimens collected were tested using the ABBOTT Alinity SĀ® Immunochemiluminescent autoanalyser. All test results were confirmed with the Roche CobasĀ® E801 and E411 auto analyser. Results: Over all prevalence for HIV was 39.39% (N=2763), HBV 7.57% (n=531) and HTLV 0.70% (N=49). Concurrent infection for HIV/HBV 4.92% (N=345), HIV/HTLV 0.36% (N=25), HBV/HTLV 0.09% (N=6) and HIV/HBV/HTLV 0.07% (N=5). Conclusion: This study confirmed an overall high prevalence of HIV and HBV infections among patients receiving blood products from the SANBS. Compared to the general population, the HIV prevalence in blood recipients was two-fold higher. Patients receiving a blood transfusion from the SANBS have high rates of HIV, HBV and HTLV which should be taken into consideration when determining donor screening strategies.en_US
dc.identifier.urihttp://hdl.handle.net/10352/558
dc.language.isoenen_US
dc.publisherVaal University of Technologyen_US
dc.subjectSouth African National Blood Servicesen_US
dc.subjectHuman T-lymphotropic virus (HTLV)en_US
dc.subjectHTLV screeningen_US
dc.subjectWorld Health Organization (WHO)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectHepatitis B (HBV)en_US
dc.subjectAcquired immunodeficiency syndrome (AIDS)en_US
dc.subject.lcshDissertations, Academic -- South Africaen_US
dc.subject.lcshHIV infections -- South Africaen_US
dc.subject.lcshAIDS (Disease)en_US
dc.subject.lcshHepatitis B virusen_US
dc.subject.lcshHTLV (Viruses)en_US
dc.titleThe prevalence of HBV, HTLV, HIV and concurrent infections in blood recipients of the South African National Blood Service (SANBS)en_US
dc.typeThesisen_US
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